Effect of Initial Cytoreductive Nephrectomy with Target Therapy versus Target Therapy Alone in Metastatic Renal Cell Carcinoma: A Single Institutional Study
نویسندگان
چکیده
منابع مشابه
Cytoreductive nephrectomy for metastatic renal cell carcinoma.
The incidence of renal cell carcinoma is increasing, with up to one-third of patients presenting with metastatic disease. Combination therapy is used to prolong survival in patients with metastatic renal cell carcinoma, which carries a poor prognosis. Although two pivotal phase 3 trials have demonstrated the efficacy of immunotherapy after cytoreductive nephrectomy for metastatic disease, for n...
متن کاملOutcome of patients with metastatic renal cell carcinoma treated with targeted therapy without cytoreductive nephrectomy.
BACKGROUND Cytoreductive nephrectomy (CN) became a standard procedure in metastatic renal cell carcinoma (mRCC) in the immunotherapy era. Historically, median overall survival (OS) of patients treated with interferon alpha (IFN-α) without CN was 7.8 months. Median OS in patients treated with targeted therapy (TT) without CN is unknown. PATIENTS AND METHODS We retrospectively reviewed records ...
متن کاملCytoreductive nephrectomy vs medical therapy as initial treatment: a rational approach to the sequence question in metastatic renal cell carcinoma.
BACKGROUND Renal cell carcinoma (RCC) can be considered as two distinct entities: localized and metastatic disease. METHODS We conducted a review of the scientific literature published within the past decade pertaining to cytoreductive nephrectomy for metastatic RCC. RESULTS Retrospective data and historical prospective series have demonstrated the survival benefit of debulking nephrectomy ...
متن کاملPerforming cytoreductive nephrectomy following targeted sunitinib therapy for metastatic renal cell carcinoma: a surgical perspective.
OBJECTIVE To describe for surgeons contemplating performing cytoreductive nephrectomy (CRN) on patients after neoadjuvant sunitinib compared to a benchmark of open radical nephrectomy, describing technical difficulties, safety and feasibility. PATIENTS AND METHODS We compared measurable surgical parameters and perioperative complications in 22 patients with metastatic renal cell carcinoma (mR...
متن کاملEffect of renal embolization in patients with synchronous metastatic renal cell carcinoma: a retrospective comparison of cytoreductive nephrectomy and systemic medical therapy
OBJECTIVE To compare survival outcomes for renal embolization (RE) to cytoreductive nephrectomy (CN) and no primary renal treatment (NT) among patients with synchronous metastatic renal cell carcinoma (mRCC) treated using either targeted therapy (TT) or immunotherapy (IT). RESULTS The median follow-up duration was 81.3 months, with a duration of first-line treatment of 3.5 months. Among the 2...
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ژورنال
عنوان ژورنال: Indonesian Journal of Cancer
سال: 2019
ISSN: 2355-6811,1978-3744
DOI: 10.33371/ijoc.v13i2.635